Extended Data Table 1. Sample sizes and characteristics of primary and replication datasets.

For each Study, grouped by broad ancestry group (Pop), Source indicates whether genotypes, sequencing data, or summary statistics were directly accessed, Dx gives the clinical source for schizophrenia diagnoses, and Screened indicates whether control participants were screened for relevant psychiatric conditions.

Pop.	Study	Source	Cases		Controls		N combined
			Dx	N	Screened?	N
AFR	CSP #572	Genotype	SCID	1,920	Yes	6,000	7,920
	MVP*	Genotype	ICD-9/10	4,488	Yes	14,065	18,553
	All of Us*	WGS	ICD-9/10	1,065	Yes	27,866	28,931
	GPC	Genotype	DI-PAD	3,506	Yes	3,849	7,355
	COGS	Genotype	DIGS	498	Yes	405	903
	MGS	Genotype	DIGS	994	Yes	1,277	2,271
	PAARTNERS	Genotype	DIGS	541	No	804	1,345
				13,012		54,266	67,278
EUR	CSP #572	Genotype	SCID	1,236	Yes	29,200	30,436
	MVP*	Genotype	ICD-9/10	5,343	Yes	126,290	131,633
	PGC3	Summary statistics	Multiple	53,386	Both	77,258	130,644
				59,965		232,748	292,713
EAS	PGC3	Summary statistics	Multiple	14,004	Both	16,757	30,761
			Totals	86,981		303,771	390,752

Abbreviations: Cooperative Studies Program (CSP); Genomic Psychiatry Cohort (GPC); Consortium on the Genomics of schizophrenia (COGS); Molecular Genetics of schizophrenia (MGS); Project Among African-Americans to Explore Risks for schizophrenia (PAARTNERS); Structured Clinical Interview for DSM-IV (SCID); International Statistical Classification of Diseases (ICD); Diagnostic Interview for Genetics Studies (DIGS); Whole-genome sequencing data (WGS).