Figure 3.

Cost function ranges. The cost range is indicated in blue color, where darker means lower cost and lighter color means higher cost. A: single action potential simulated by the model. Features in the cost function included AP peak amplitude, half spike duration, AHP, and baseline potential. B: several in vitro rat STN slice recordings when hyperpolarization currents were injected (34). Point (a) checks the minimum potential, point (b) checks the midway potential, and point (c) checks the ending potential of the sag. C: the experimental average of F-I curve derived from several in vitro rat STN slices recording studies (30, 34, 35). Four checkpoints at 0, 0.04, 0.1, and 0.16 nA current injections were used in the cost function. AHP, afterhyperpolarization potential; STN, subthalamic nucleus.