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[Preprint]. 2024 Aug 31:2024.08.30.610540. [Version 1] doi: 10.1101/2024.08.30.610540

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Figure 4. — A. Comparison of the impact of chronic sEH inhibition on myogenic responses of middle cerebral arteries (MCAs). B. Comparison of the impact of chronic sEH inhibition on myogenic responses of parenchymal arterioles (PAs). Both comparisons are made between age-matched diabetic T2DN (DM) vs. Sprague Dawley (SD) rats and TgF344-AD (AD) vs. F344 rats. The rats were treated with a vehicle (1% PEG-400 in drinking water) or the sEH inhibitor TPPU (1 mg/kg/day) for 9 weeks. Mean values ± SEM are presented, with 6–16 rats per group. * denotes p < 0.05 for comparisons between the corresponding values in AD or DM-ADRD rats compared to their respective control rats. † denotes p < 0.05 for comparisons between the corresponding values obtained from TPPU-treated rats compared to vehicle-treated rats within the same strain.