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[Preprint]. 2024 Aug 30:2024.08.29.610348. [Version 1] doi: 10.1101/2024.08.29.610348

Figure 4. Impaired inhibitory synapse function in Pcp2Cre;Dag1cKO Purkinje cells at P60 but not P25.

Figure 4.

(A-F) mIPSC analysis in Pcp2Cre;Dag1cKO and littermate control Purkinje cells at P25. (A) Average mIPSC event. (B) Representative 15 second trace of mIPSCs. (C-D) mIPSC amplitude (C) and frequency (D); error bars are presented as mean + SEM. (E-F) Cumulative frequency histogram for individual mIPSC amplitudes (E) and inter-event intervals (IEI) (F). (G-L) mIPSC analysis in Pcp2Cre;Dag1cKO and littermate control Purkinje cells at P60. (G) Average mIPSC event. (H) Representative 15 second trace of mIPSCs. (I-J) mIPSC amplitude (I) and frequency (J); error bars are presented as mean + SEM. (K-L) Cumulative frequency histogram for individual mIPSC amplitudes (K) and inter-event intervals (IEI) (L). P25 Pcp2Cre;Dag1Ctrl N = 13 cells, 5 animals. P25 Pcp2Cre;Dag1cKO N = 9 cells , 5 animals. P60 Pcp2Cre;Dag1Ctrl N = 12 cells, 5 animals. P60 Pcp2Cre;Dag1cKO N = 14 cells , 4 animals.