Table 1.

The most significant up-regulated and down-regulated GO Biological Process pathways from M. fortuitum-infected ALoCs containing macrophages

Direction	GO Biological Process	Statistic	Genes	adj.Pval
Up	Response to bacterium	7.3996	438	1.1e-09
	Humoral immune response	6.5518	138	6.0e-07
	Defense response to bacterium	6.3097	169	1.1e-06
	Antimicrobial humoral response	6.0602	65	1.9e-05
	Response to molecule of bacterial origin	5.5061	251	3.7e-05
	Chemotaxis	5.2453	444	8.2e-05
	Taxis	5.2402	445	8.2e-05
	Response to lipopolysaccharide	5.2654	240	8.2e-05
	Antimicrobial humoral immune response mediated by antimicrobial peptide	5.6504	41	1.4e-04
Down	MRNA processing	−6.8939	402	4.4e-08
	RNA splicing	−6.5273	385	2.3e-07
	Histone modification	−5.7112	429	1.6e-05
	Proteasome-mediated ubiquitin-dependent protein catabolic process	−5.5755	410	2.5e-05
	Proteasomal protein catabolic process	−5.534	470	2.5e-05
	Chromatin organization	−5.4523	478	3.2e-05
	NcRNA metabolic process	−5.3774	477	4.2e-05
	Peptidyl-lysine modification	−5.128	343	1.5e-04
	RNA splicing via transesterification reactions with bulged adenosine as nucleophile	−5.1146	265	1.5e-04
	MRNA splicing via spliceosome	−5.1146	265	1.5e-04
	RNA splicing via transesterification reactions	−5.097	269	1.5e-04