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. 2024 Jul 12;8(9):1654–1666. doi: 10.1038/s41559-024-02461-1

Fig. 2. Probabilistic estimates of metabolic networks from modern life that were present in LUCA.

Fig. 2

In black: enzymes and metabolic pathways inferred to be present in LUCA with at least PP = 0.75, with sampling in both prokaryotic domains. In grey: those inferred in our least-stringent threshold of PP = 0.50. The analysis supports the presence of a complete WLP and an almost complete TCA cycle across multiple confidence thresholds. Metabolic maps derived from KEGG47 database through iPath109. GPI, glycosylphosphatidylinositol; DDT, 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane.