Table 1.

Assessment Elements (AE) used in Testing proposal Evaluation (TPE) submissions and decisions. See Supplemental Table 2 for a detailed explanation of each AE.

Assessment Elements Based on Toxicodynamic and Other Considerations		Assessment Elements Based on Toxicokinetic Considerations
AE.1	Structure/Physicochemical Properties	AE.9	Formation of Common (Identical) Compounds
AE.2	Common Biological Targets with Common Metabolites	AE.10	Exposure of Biological Targets to Common Compounds
AE.3	Common Biological Targets without Common Metabolites (Qualitative)	AE.11	Extent of the Bioavailability of the Parent Compound
AE.4	Common Biological Targets without Common Metabolites (Quantitative)	AE.12	Formation and Impact of Non-common Compounds/Exposure to Other Compounds than those Linked to the Prediction
AE.5	Environmental Degradation to Non-common Compounds	AE.13	Metabolites of Source and Target have been Identified
AE.6	Environmental Bioaccumulation of Potential Non-common Compounds	AE.14	Potential Presence of Uncharacterized Metabolites or Impurities
AE.7	Common Environmental Degradation Pathways	Other Assessment Elements
AE.8	Toxicodynamic Similarity based on the Data from a Bridging (OECD Test Guideline) Study	AE.15	Characterization of Constituents (for Multi-Constituent or UVCB Substances)
		AE.16	Toxicodynamic Similarity based on the Data from a Bridging (Not a Guideline) Study
		AE.17	Lack of Observed Adverse Effects