Table 7.
Multinomial logistic regression of estimation coefficient (β), 95% CIs and p-values of risk factors found in our study among patients with malignant tumors using patients with mixed GCT as the dependent variable
|
Risks |
n (%) |
IT total n , β coefficient ( p -value) |
YST total n , β coefficient ( p -value) |
DYS total n , β coefficient ( p -value) |
GrCT total n , β coefficient ( p -value) |
RMS total n , β coefficient ( p -value) |
ADC total n , β coefficient ( p -value) |
|
Univariate |
|||||||
|
Obesity |
72 (73.5%) |
16, 0.04 (0.953) |
6, 0.08 (0.316) |
7, 0.045 (0.958) |
5, 0.40 (0.733) |
9, 0.62 (0.396) |
3, 0.80 (0.436) |
|
Mother’s age [years] |
|||||||
|
≤20 |
18 (18.4%) |
Constant |
|||||
|
>20–25 |
17 (17.3%) |
3, 0.18 (0.872) |
0, -16.12 (0.994) |
2, -0.47 (0.736) |
0, 17.04 (0.995) |
5, 0.10 (0.100) |
0, 16.82 (0.990) |
|
>25–30 |
15 (15.3%) |
5, 0.51 (0.629) |
2, -0.41 (0.733) |
0, -15.58 (0.994) |
0, 17.09 (0.994) |
2, -1.10 (0.309) |
0, 16.86 (0.995) |
|
>30–35 |
18 (18.4%) |
5, 0.92 (0.403) |
2, 0.10 (1.000) |
2, 0.69 (0.624) |
2, 0.41 (0.726) |
2, -0.69 (0.535) |
0, 16.22 (1.000) |
|
>35–40 |
30 (30.6%) |
6, 0.54 (0.600) |
4, 0.13 (0.901) |
4, 0.83 (0.519) |
1, 1.66 (0.207) |
1, -1.95 (0.129) |
3, 0.15 (0.889) |
|
Breastfeeding ≤5 months |
72 (73.5%) |
12, -0.52 (0.393) |
7, 0.04 (0.964) |
7, 0.44 (0.626) |
6, 15.71 (0.992) |
12, 0.98 (0.262) |
5, 15.71 (0.993) |
|
DSD |
10 (10.2%) |
2, -0.210 (0.824) |
1, 14.590 (0.991) |
4, 15.001 (0.100) |
1, 0.78 (0.437) |
0, -0.245 (0.802) |
0, -14.604 (0.994) |
|
Stress |
70 (71.4%) |
15, 0.52 (0.454) |
6, 1.03 (0.206) |
5, 1.21 (0.147) |
3, 2.13 (0.033) |
11, 0.14 (0.868) |
5, 13.01 (0.983) |
|
Hormone |
15 (15.3%) |
3, -0.36 (0.654) |
0, -15.2 (0.991) |
2, 0.18 (0.846) |
1, -0.18 (0.885) |
3, 0.14 (0.868) |
0, 15.27 (0.994) |
|
Smoking |
69 (70.4%) |
13, 0.33 (0.599) |
6, -0.41 (0.600) |
6, -0.12 (0.886) |
4, -0.12 (0.903) |
12, 0.98 (0.262) |
1, 0.58 (0.630) |
|
Positive heredo-genetic history |
47 (48.0%) |
8, -0.64 (0.284) |
6, 0.25 (0.740) |
3, -0.85 (0.295) |
1, -1.76 (0.130) |
7, -0.15 (0.816) |
3, 0.25 (0.800) |
|
Abnormal birth weight |
25 (25.5%) |
4, -0.64 (0.363) |
4, 0.41 (0.600) |
2, -0.44 (0.626) |
1, -0.80 (0.497) |
4, -0.11 (0.885) |
0, -14.79 (0.989) |
|
Residence area (rural) |
59 (60.2%) |
10, -0.91 (0.137) |
6, -0.41 (0.600) |
4, -1.03 (0.193) |
5, 0.80 (0.497) |
10, 0.11 (0.885) |
2, -1.22 (0.227) |
|
Pollution |
70 (71.4%) |
10, 1.8 (0.010) |
6, 1.30 (0.124) |
6, 1.01 (0.257) |
5, 0.10 (0.938) |
13, 0.86 (0.463) |
3, 1.30 (0.221) |
|
Rh positive |
81 (82.7%) |
8, 2.97 (0.001) |
10, 15.00 (1.000) |
9, 14.60 (0.993) |
6, 13.70 (1.000) |
14, 14.00 (0.992) |
5, 14.64 (0.995) |
|
No postnatal vitamin D |
20 (20.4%) |
0, -15.28 (0.985) |
2, 0.18 (0.842) |
2, -0.05 (0.958) |
3, 1.20 (0.200) |
6, 0.92 (0.199) |
1, -0.18 (0.880 |
|
No postnatal vaccination |
18 (18.4%) |
8, 0.72 (0.267) |
1, -1.00 (0.389) |
1, -0.88 (0.450) |
1, -0.41 (0.733) |
0, -15.40 (0.988) |
0, -15.30 (1.000) |
|
Menstrual disorders |
25 (25.5%) |
5, 0.87 (0.275) |
1, -0.16 (0.895) |
5, 2.26 (0.013) |
4, 2.73 (0.010) |
2, 0.25 (0.802) |
2, 1.63 (0.138) |
|
Malformations |
77 (78.6%) |
18, 0.36 (0.655) |
7, -0.59 (0.490) |
8, 0.64 (0.582) |
4, -0.74 (0.457) |
9, 0.85 (0.257) |
5, 13.52 (0.986) |
|
UTI |
45 (45.9%) |
11, -0.06 (0.920) |
4, -0.56 (0.459) |
3, -0.85 (0.295) |
2, -0.85 (0.373) |
9, 0.43 (0.525) |
1, -1.54 (0.194) |
|
Multivariate |
|||||||
|
Stress |
70 (71.4%) |
15, 1.39 (0.114) |
6, 0.91 (0.276) |
5, 1.2 (0.180) |
3, 2.10 (0.048) |
11, 0.08 (0.926) |
5, 14.42 (0.990) |
|
Pollution |
70 (71.4%) |
10, 1.75 (0.041) |
6,1.27 (0.138) |
6, 0.82 (0.388) |
5, 0.12 (0.930) |
13, 0.88 (0.452) |
3, 1.19 (0.277) |
|
Rh positive |
81 (82.7%) |
8, 3.41 (0.001) |
10, 15.07 (0.100) |
9, 14.45 (0.994) |
6, 13.62 (0.100) |
14, 14.92 (0.993) |
5, 15.00 (0.900) |
|
Menstrual disorders |
25 (25.5%) |
5, 0.95 (0.343) |
1, -0.25 (0.840) |
5, 2.22 (0.017) |
4, 2.80 (0.013) |
2, 0.26 (0.794) |
2, 1.46 (0.196) |
AC: Adenocarcinoma; CI: Confidence interval; DSD: Disorder of sex development; DYS: Dysgerminoma; GCT: Germ cell tumor; GrCT: Granulosa cell tumor; IT: Immature teratoma; n: No. of cases; Rh: Rhesus; RMS: Rhabdomyosarcoma; UTI: Urinary tract infection; YST: Yolk sac tumor