Figure 5.

Downstream analysis of disease states with SCGP-identified partitions

(A) Three representative samples of different DKD classes are illustrated; note the fibrosis of glomeruli and increase in the area of the basement membrane partition (light blue-colored nodes). Glomeruli are segmented by dashed circles.

(B) Boxplot shows that the area proportion of the basement membrane partition significantly increases (p < 0.001, Jonckheere-Terpstra test) in DKD samples. Each dot represents a tissue sample.

(C) Expression of native proteins (CCR6) significantly decreases (p < 0.001, Jonckheere-Terpstra test) in glomeruli of patients with DKD. Each dot represents an individual glomerulus, and each box summarizes glomeruli from one patient. Note the heterogeneity observed within a single tissue sample (A, bottom row) and between patients from the same DKD class.

(D) Two samples from the UCSF Derm dataset with different skin conditions are illustrated.

(E) Area proportion of the immune aggregate partition significantly increases in atopic dermatitis samples (p < 0.001, two-sided two-sample t test).

(F) Epidermal layers show significant thickening in atopic dermatitis samples (p < 0.001, two-sided two-sample t test).