Figure 6.

Annotation of major structures in TMEs by SCGP

(A) Coarse partitioning identified tumor/stroma regions in TMEs.

(B) ARIs and F1 scores were calculated between unsupervised annotations and manual tumor/stroma annotations. SCGP achieved significantly better performances than other methods (Wilcoxon signed-rank test).

(C) Fine-grained partitions detected additional tissue structures in TMEs.

(D) Heatmaps show distinct cell-type enrichment and protein expression profiles of different tissue structures identified by SCGP.

See also Figure S9.