Table 1.
Characteristics of patients with and without positive FUBC
| Characteristic | Positive FUBC (n = 42) | Negative FUBC (n = 106) | P value |
|---|---|---|---|
| Median age, y (IQR) | 60.5 (44.0–69.0) | 59.0 (49.0–69.0) | 0.8152 |
| Male, n (%) | 23 (54.8) | 59 (55.7) | 0.921 |
| Medical ICU, n (%) Non-medical ICU, n (%) |
31 (73.8) 11 (26.2) |
67 (63.2) 39 (36.8) |
0.2189 |
| Median quick Pitt bacteraemia score (IQR) | 3 (2–3) | 2 (1–3) | 0.0425 |
| Haemodialysis or renal replacement therapy, n (%) | 5 (11.9) | 19 (17.9) | 0.3704 |
| Organism, n (%) | 0.672 | ||
| E. coli | 18 (42.9) | 38 (35.8) | |
| K. pneumoniae | 9 (21.4) | 17 (16.0) | |
| E. cloacae | 3 (7.1) | 10 (9.4) | |
| Pseudomonas spp. | 4 (9.5) | 9 (8.5) | |
| MDR, n (%) | 14 (33.3) | 17 (16) | 0.0197 |
| Non-lactose-fermenting bacteriaa, n (%) | 8 (19) | 32 (30.2) | 0.1688 |
| Source, n (%) | 0.791 | ||
| Urinary | 11 (26.2) | 34 (32.1) | |
| Respiratory | 7 (16.7) | 25 (23.6) | |
| Intra-abdominal | 12 (28.6) | 19 (17.9) | |
| IV catheter | 4 (9.5) | 11 (10.4) | |
| Skin/soft tissue | 1 (2.4) | 4 (3.8) | |
| Other | 2 (4.8) | 3 (2.8) | |
| Unclear | 5 (11.9) | 10 (9.4) | |
| Immunocompromised, n (%) | 16 (38.1) | 21 (19.8) | 0.0206 |
| Cardiac device or hardware, n (%) | 0 (0) | 4 (3.8) | 0.578 |
| Permanent pacemaker | 0 (0) | 2 (1.8) | — |
| Bioprosthetic valve | 0 (0) | 2 (1.8) | — |
| Median length of stay, d (IQR) | 17.5 (9.0–33.0) | 17.0 (8.0–28.0) | 0.9474 |
| Median time from index to FUBC, h (IQR) | 35.2 (28.2–42.0) | 44.2 (33.2–55.4) | 0.0013 |
| Median time to appropriate antibiotic, h (IQR) | 14.0 (3.7–35.8), n = 33b | 10.0 (1.0–30.6), n = 77b | 0.1151 |
| Fever, n (%) | 18 (42.9) | 24 (22.6) | 0.0139 |
| Vasopressor use, n (%) | 25 (59.5) | 36 (34) | 0.0044 |
| Source control achieved, n (%) | 0 (0) | 29 (27.4) | 0.0004 |
| Time from admission to index culture, h, median (IQR) | 1.34 (0.525–11.35) | 2.86 (0.66–11.695) | 0.4749 |
| Median duration of antimicrobial therapy, d (IQR) | |||
| Overall | 7.39 (3.21–15.50), n = 41c | 7.72 (4.23–14.46), n = 106 | 0.8404 |
| Among those who expired during stay | 2.90 (0.96–7.39), n = 18 | 5.60 (3.30–12.30), n = 41 | 0.0997 |
| Among those who did not expire during stay | 13.51 (6.47–17.53), n = 23 | 9.45 (5.60–14.46), n = 65 | 0.1410 |
Bold values in RH column as presume they indicate statistical significance.
aNon-lactose-fermenting bacteria included: Pseudomonas spp., Proteus spp., Acinetobacter spp., Burkholderia spp., Stenotrophomonas spp., Morganella morganii and Serratia spp.
bPatients with appropriate antimicrobial administered after index blood culture received by microbiology laboratory. Patients with appropriate antimicrobial administration prior to blood culture drawn were not included.17
cOne patient with MDR Pseudomonas bacteraemia did not receive an active antimicrobial prior to time of death.