Table 2.
Drugs inducing secondary hypercholesterolemia and hypertriglyceridemia
| Severity (% elevation) | HyperLDL-cholesterolemia | Hypertriglyceridemia |
|---|---|---|
| Severe (≥ 50) | Steroid hormones | |
| Oral contraceptives with 2nd/3rd gen. progestogens | ||
| Dermatologic drugs | ||
| Isotretinoin, acitretin | ||
| Anti-infective agents | ||
| Ritonavir (200–300%) | ||
| Anti-cancer drugs | ||
| L-asparaginase | ||
| Moderate (10–50) | Steroid hormones | Cardiovascular drugs |
| Danazol, glucocorticoid (variable) | β-blockers | |
| Anti-infective agents | Steroid hormones | |
| Ritonavir, indinavir, nelfenavir | Unopposed estrogens, tamoxifen, glucocorticoid (variable) | |
| Immunosuppressants (variable) | Antipsychotics | |
| Cyclosporin, rapamycin | Clozapine, olanzapine, haloperidol | |
| Immunosuppressants (variable) | ||
| Cyclosporin, rapamycin | ||
| Anti-infective agents (variable) | ||
| Indinavir, nelfinavir | ||
| Mild (< 15) | Cardiovascular drugs | Cardiovascular drugs |
| Thiazide, loop diuretics | Thiazide, loop diuretics | |
| Steroid hormones | ||
| Unopposed progestogens (testosterone derivatives) | ||
| Oral contraceptives with 2nd gen progestogens | ||
| Dermatologic drugs | ||
| Isotretinoin | ||
| Anticonvulsants | ||
| Carbamazepine, phenytoin, phenobarbital |
Variable: 0–70%.