Table 1.
Characteristics of study participants
| Category | Group 1 | Group 2 | p-value | 95% CI |
|---|---|---|---|---|
| Hysteroscopic adhesiolysis | Yes | Yes | - | - |
| ADMSC treatment | No | Yes | - | - |
| Sample size (n) | 20 | 21 | - | - |
| Age (years) | 37.9 ± 5.9 | 40.0 ± 4.7 | 0.2160 | -1.277 to 5.477 |
| BMI (kg/m2) | 26.2 ± 3.2 | 24.8 ± 2.4 | 0.1135 | -3.175 to 0.3520 |
| Infertility duration (years) | 4.6 ± 3.2 | 3.5 ± 3.2 | 0.2500 | -3.152 to 0.8448 |
| Previous IVF cycles with implantation failure (n)a | 0.6 ± 0.8 | 0.8 ± 0.9 | 0.4494 | -0.3451 to 0.7642 |
| No. of patients with canceled ET | 11 | 9 | - | - |
| No. of patients with at least one failed cycle | 9 | 12 | - | - |
| AS classification at the time of enrollment | ||||
| Removed IUA at the time of ADMSC application | Not applicable | 33.3% (7/21) | ||
| Stage I, mild | 55.0% (11/20) | 42.9% (9/21) | ||
| Stage II, moderate | 30.0% (6/20) | 14.3% (3/21) | ||
| Stage III, severe | 15.0% (3/20) | 9.5% (2/21) | ||
Abbreviations: 95% CI: 95% confidence interval; ADMSC: adipose-derived mesenchymal stem cells; AS: Asherman’s syndrome; BMI: Body-Mass Index; IVF: in vitro fertilization; ET: embryo transfer; IUA: intrauterine adhesions. Values are percentage (frequency) or average ± standard deviation. P-value was calculated using an unpaired t-test.
a
The mean of previous IVF cycles with implantation failure is below one as for some patients with poor quality endometrium; their embryo transfer was canceled.
AS classification according to the American Fertility Society 1988 at the time of enrollment [17].