Table 2.

Plasma pharmacokinetic parameters of norLAAM following administration of nor-LAAM to rabbits (mean ± SD, n = 3).

Formulation	Nor-LAAM solution	No-LAAM solution	Nor-LAAM-MPs
Route of administration	IV (0.1 mg/kg)	PO (1mg/kg)	SQ (5mg/kg)
AUCinf (h×ng/mL)	124.5 ± 39.6	343.8 ± 90.7	5110.7 ± 1082.2
AUC0→t (h×ng/mL)	96.5 ± 17.0	299.7 ± 128.8	4932.5 ± 932.6
Cmax or C0 (ng/mL)	54.0 ± 26.2	37.0 ± 13.7	64.5 ± 24.3
tmax (h)	—	0.25	8
t1/2 (h)	3.9 ± 1.7	13.7 ± 3.6	55.3 ± 9.3
CL (mL/h/kg)	866.5 ± 330.1	—	—
Vss (mL/kg)	4726.5 ± 18996.3	—	—
F (%)	—	27.6 ± 22.9	82.1 ± 54.7 *

AUC_inf, area under the curve from time zero to infinity; AUC_0→t, area under the curve from time zero to the last sampling time point; C_max, maximum observed concentration; t_1/2, half-life. Significant differences between PO and SQ:

^*p ≤ 0.05.