Table 3.
Anthropometric and dietary variables
| DIC (n = 7) | non-DIC (n = 19) | p-value (group) | p-value (time) | p-value (interaction) | |||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline DOX treatment | Completion of DOX treatment | One-year follow-up | Baseline DOX treatment | Completion of DOX treatment | One-year follow-up | ||||
| Body weight (kg) | 83.2 ± 24.3 | 82.0 ± 21.5 | 81.7 ± 21.0 | 72.6 ± 15.7 | 74.0 ± 15.9 | 73.4 ± 17.0 | 0.314 | 0.994 | 0.271 |
| BMI (kg/m2) | 32.6 ± 9.3 | 32.2 ± 8.8 | 31.8 ± 8.3 | 28.9 ± 6.7 | 29.6 ± 6.3 | 28.2 ± 5.6 | 0.389 | 0.676 | 0.208 |
| Low weight (n) | 0 | 0 | 0 | 0 | 1 | 0 | --- | --- | --- |
| Normal weight (n) | 3 | 3 | 3 | 6 | 3 | 5 | --- | --- | --- |
| Overweight (n) | 0 | 0 | 0 | 6 | 7 | 7 | --- | --- | --- |
| Obesity I (n) | 0 | 1 | 0 | 4 | 5 | 3 | --- | --- | --- |
| Obesity II (n) | 3 | 1 | 3 | 2 | 1 | 1 | --- | --- | --- |
| Obesity III (n) | 1 | 2 | 1 | 1 | 2 | 1 | --- | --- | --- |
| Fat mass (%) | 42.5 ± 11.7 | 40.8 ± 8.6 | 41.4 ± 10.5 | 39.4 ± 8.0 | 39.6 ± 8.2 | 38.8 ± 6.5 | 0.628 | 0.646 | 0.408 |
| Muscle mass (%) | 23.8 ± 3.6 | 25.6 ± 3.3 | 25.4 ± 4.2 | 26.0 ± 2.6 | 26.6 ± 3.9 | 26.0 ± 2.4 | 0.429 | 0.054 | 0.059 |
| Visceral fat (rating) | 11.4 ± 5.2 | 10.4 ± 4.5 | 10.9 ± 5.0 | 8.9 ± 3.7 | 9.5 ± 3.6* | 8.5 ± 2.4 | 0.375 | 0.581 | 0.007 |
| Neck circumference (cm) | 36.7 ± 4.4 | 37.7 ± 4.8 | 36.2 ± 5.3 | 34.9 ± 2.9 | 35.6 ± 3.6 | 34.8 ± 2.8 | 0.330 | 0.027 | 0.425 |
| Waist circumference (cm) | 103.7 ± 16.9 | 102.8 ± 14.4 | 99.8 ± 16.7 | 96.2 ± 14.2 | 97.7 ± 14.4 | 100.3 ± 10.0* | 0.513 | 0.898 | 0.002 |
| Total calorie intake (kcal) | 1378.6 ± 362.8 | 1499.5 ± 352.6 | 1467.8 ± 361.9 | 1601.2 ± 467.5 | 1321.9 ± 424.3 | 1623.4 ± 434.2 | 0.569 | 0.350 | 0.122 |
| Carbohydrates (g) | 55.4 ± 10.1 | 50.3 ± 3.2 | 54.3 ± 4.7 | 54.4 ± 10.0 | 53.0 ± 7.7 | 55.5 ± 5.2 | 0.636 | 0.020 | 0.559 |
| Proteins (g) | 19.0 ± 3.7 | 17.5 ± 2.9 | 19.1 ± 4.7 | 18.4 ± 4.8 | 17.8 ± 4.0 | 16.7 ± 3.9 | 0.340 | 0.594 | 0.233 |
| Lipids (g) | 25.6 ± 8.7 | 32.2 ± 3.4 | 26.7 ± 5.4 | 27.3 ± 9.0 | 29.2 ± 5.9 | 26.7 ± 7.5 | 0.868 | < 0.001 | 0.088 |
| Cholesterol (g) | 336.4 ± 217.1 | 238.9 ± 133.0 | 289.5 ± 168.3 | 266.9 ± 171.0 | 223.8 ± 156.1 | 238.9 ± 160.4 | 0.227 | 0.529 | 0.906 |
| Saturated fat (g) | 13.3 ± 6.9 | 20.2 ± 7.9 | 15.6 ± 5.4 | 17.9 ± 8.3 | 16.9 ± 8.3 | 18.7 ± 8.0 | 0.578 | 0.336 | 0.072 |
| Sodium (mg) | 2123.1 ± 868.4 | 2734.2 ± 1479.9 | 1881.7 ± 891.4 | 1966.9 ± 1142.5 | 1510.5 ± 933.4 | 1683.7 ± 847.4 | 0.085 | 0.133 | 0.148 |
DIC, DOX-induced cardiotoxicity; non-DIC, non-DOX-induced cardiotoxicity; BMI, body mass index. Data expressed as mean ± standard error or absolute value (n). Generalized estimating equations (GEE) method with Bonferroni post-hoc test was used; * p < 0.05 versus baseline within the group