REAGENT or RESOURCE	SOURCE	IDENTIFIER
Biological samples
Serum samples from patients	The Seventh Affiliated Hospital of Sun Yat-Sen University	This paper
Serum samples from patients	Shenzhen People’s Hospital	This paper
Serum samples from patients	Sun Yat-sen University Cancer Center	This paper
Critical commercial assays
Human PF4 ELISA Kit	Neobioscience	EHC135.96
EVs extraction Kit	Echobiotech	ES9P11e
Human AACT ELISA Kit	FineTest	EH0570
Deposited data
Mass spectrometry data	iProX database	IPX0008187000
Single-cell RNA sequencing data	GEO database	GEO: GSE178341, GSE132465
TCGA CRC dataset	TCGA database	https://gdc.cancer.gov/about-data/publications/pancanatlas
Software and algorithms
R (version 4.2.3)	R Project	https://www.r-project.org
SPSS 26.0	IBM	RRID:SCR_002865