Table 2.
Multivariable-adjusted mean values of the volumes of the hippocampus and hippocampal subregions according to hemoglobinA1c levels
| Hemoglobin A1c levels, % | p for trend | q value of FDR correction | ||||
|---|---|---|---|---|---|---|
| <5.7 (n = 3406) | 5.7–6.4 (n = 2989) | ≥6.5 (n = 795) | ||||
| Whole hippocampus, HV, mm3 | 6187.727 (6144.512–6230.942) | 6193.960 (6149.737–6238.183) | 6122.181 (6067.664–6176.698) | 0.003* | – | |
| Hippocampal subregions | ||||||
| HATA, HV, mm3 | 97.152 (95.889–98.416) | 96.858 (95.565–98.152) | 95.597 (94.003–97.191) | 0.046* | 0.069 | |
| Fimbria, HV, mm3 | 102.353 (99.642–105.064) | 99.652 (96.878–102.427) | 93.592 (90.172–97.012) | <0.001* | <0.001† | |
| Hippocampal fissure, HV, mm3 | 346.103 (342.022–350.184) | 348.721 (344.545–352.898) | 350.870 (345.721–356.019) | 0.025* | 0.060 | |
| Molecular_layer, HV, mm3 | 803.394 (796.486–810.303) | 805.025 (797.955–812.094) | 796.674 (787.959–805.389) | 0.049* | 0.065 | |
| GC ML DG, HV, mm3 | 540.797 (536.343–545.251) | 540.954 (536.396–545.511) | 535.250 (529.632–540.869) | 0.026* | 0.052 | |
| CA1, HV, mm3 | 1211.672 (1201.436–1221.908) | 1213.804 (1203.328–1224.279) | 1203.977 (1191.063–1216.890) | 0.150 | 0.180 | |
| CA3, HV, mm3 | 397.392 (393.178–401.607) | 399.835 (395.523–404.148) | 395.177 (389.860–400.494) | 0.038* | 0.065 | |
| CA4, HV, mm3 | 478.310 (474.420–482.201) | 479.303 (475.322–483.284) | 475.788 (470.880–480.696) | 0.180 | 0.196 | |
| Subiculum, HV, mm3 | 838.303 (831.211–845.395) | 836.156 (828.898–843.413) | 824.620 (815.673–833.567) | <0.001* | 0.002† | |
| Presubiculum, HV, mm3 | 560.557 (554.904–566.210) | 557.340 (551.555–563.125) | 550.431 (543.300–557.562) | 0.001* | 0.004† | |
| Parasubiculum, HV, mm3 | 109.487 (107.416–111.557) | 108.293 (106.174–110.412) | 108.706 (106.094–111.318) | 0.180 | 0.196 | |
| Hippocampal tail, HV, mm3 | 1048.310 (1037.476–1059.144) | 1056.740 (1045.653–1067.827) | 1042.368 (1028.701–1056.036) | 0.006* | 0.018† | |
CA Cornu Ammonis, eTIV estimated intracranial volume, FDR false discovery rate, GC ML DG granule cell and molecular cell layer of the dentate gyrus, HATA hippocampus amygdala transition area, HV hippocampal volume. Values are shown as multivariable-adjusted mean values (95% confidence intervals) where values are calculated as follows: (left + right) volumes of hippocampus or hippocampal subregions. Adjusted for age, sex, educational level, research site, apolipoprotein E Ɛ4, body mass index, hypertension, serum low-density lipoprotein cholesterol, serum high-density lipoprotein cholesterol, current smoking habits, current alcohol intakes, regular exercise, eTIV. *p for trend <0.05. †q value of FDR correction <0.05.