Table 4.
Multivariable-adjusted mean values of the volumes of the hippocampus and hippocampal subregions according to homeostasis model assessment of β cell function (HOMA-β) levels
| HOMA-β levels | p value | q value of FDR correction | ||
|---|---|---|---|---|
| ≤30 (n = 257) | >30 (n = 2840) | |||
| Whole hippocampus, HV, mm3 | 6121.331 (6024.162–6218.500) | 6208.870 (6132.305–6285.434) | 0.013* | – |
| Hippocampal subregions | ||||
| HATA, HV, mm3 | 93.744 (90.970–96.518) | 95.459 (93.273–97.645) | 0.087 | 0.130 |
| Fimbria, HV, mm3 | 101.041 (94.801–107.281) | 108.221 (103.304–113.138) | 0.001* | 0.012† |
| Hippocampal fissure, HV, mm3 | 341.212 (0332.141–350.284) | 337.296 (330.148–344.444) | 0.232 | 0.253 |
| Molecular_layer, HV, mm3 | 870.085 (854.298–885.872) | 880.248 (867.808–892.687) | 0.075 | 0.150 |
| GC ML DG, HV, mm3 | 526.831 (517.148–536.515) | 535.342 (527.712–542.972) | 0.015* | 0.09 |
| CA1, HV, mm3 | 1183.722 (1160.750–1206.694) | 1198.105 (1180.004–1216.205) | 0.083 | 0.142 |
| CA3, HV, mm3 | 390.998 (381.655–400.342) | 395.505 (388.142–402.867) | 0.182 | 0.242 |
| CA4, HV, mm3 | 465.290 (456.866–473.713) | 471.411 (464.773–478.048) | 0.044* | 0.132 |
| Subiculum, HV, mm3 | 813.709 (798.120–829.297) | 825.507 (813.224–837.790) | 0.036* | 0.144 |
| Presubiculum, HV, mm3 | 540.658 (528.446–552.870) | 545.982 (536.360–555.605) | 0.227 | 0.272 |
| Parasubiculum, HV, mm3 | 109.341 (104.803–113.879) | 109.044 (105.469–112.620) | 0.856 | 0.856 |
| Hippocampal tail, HV, mm3 | 1025.912 (1001.013–1050.811) | 1044.046 (1024.427–1063.665) | 0.044* | 0.132 |
CA Cornu Ammonis, eTIV estimated intracranial volume, FDR false discovery rate, GC ML DG granule cell and molecular cell layer of the dentate gyrus, HATA hippocampus amygdala transition area, HOMA-β homeostasis model assessment of beta cell function, HV hippocampal volume. Values are shown as multivariable-adjusted mean values (95% confidence intervals), where values are calculated as follows: (left + right) volumes of hippocampus or hippocampal subregions. Adjusted for age, sex, educational level, research site, apolipoprotein E Ɛ4, body mass index, hypertension, serum low-density lipoprotein cholesterol, serum high-density lipoprotein cholesterol, current smoking habits, current alcohol intakes, regular exercise, eTIV. *p for trend <0.05. †q value of FDR correction <0.05.