REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-SOX7 Antibody	R&D	Cat# AF2766; RRID: AB_2196241
Anti-BAX Antibody	Cell Signaling	Cat# 2774; RRID: AB_490806
Anti-BCL-2 Antibody	Cell Signaling	Cat# 26295; RRID: AB_2798920
Anti-GAPDH Antibody	Abcam	Cat# ab8245; RRID: AB_2107448
HRP-conjugated anti-rabbit Antibody	Cell Signaling	Cat# 7074P2; RRID: AB_2099233
Donkey anti-goat Antibody	Life technologies	Cat# A-11055; RRID: AB_2534102
Bacterial and virus strains
Limosilactobacillus reuteri DSM 17938	CGMCC	Cat# 1.12733
Chemicals, peptides, and recombinant proteins
β-RA	Macklin	Cat# D806751
Cisplatin	Macklin	Cat# D807330
Vancomycin	Macklin	Cat# V871983
Neomycin sulfate	Macklin	Cat# N6063
Metronidazole	Macklin	Cat# M813525
Ampicillin	Macklin	Cat# A830931
Paraformaldehyde	Macklin	Cat# P885233
Glutaraldehyde	Macklin	Cat# G810415
LC/MS -grade methanol	Sigma	Cat# 1.06035
Formic acid	Macklin	Cat# F809712
Acetonitrile	Sigma	Cat# CN34891
Hyaluronidase	Sigma	Cat# H4272
Formaldehyde	Sigma	Cat# 252549
Glycerine	Macklin	Cat# 810575
Sodium bicarbonate	Macklin	Cat# S818079
Sodium diethyldithiocarbamate	Macklin	Cat# S817628
Pregnant mare serum gonadotropin	Ningbo Second Hormone Factory	Cat# GN024
Human chorionic gonadotropin	Ningbo Second Hormone Factory	Cat# GN026
Hyaluronidase	Sigma	Cat# H1115000
de Man, Rogosa and Sharpe broth	Hopebio	Cat# HB0384-5
DMEM	Gibco	Cat# C11995500BT
DMEM/F12(1:1) medium	Gibco	Cat# C11330500BT
0.25%Trysin-EDTA	Gibco	Cat# 25200072
Bovine Serum Albumin	Sigma	Cat# V900933
Opti-MEN	Gibco	Cat# 31985070
TRIzol reagent	Invitrogen	Cat# 15596018
RIPA lysis buffer	Thermo Scientific	Cat# 89901
Protease and phosphatase inhibitors	Thermo Scientific	Cat# 78442
HTF medium	Nanjing Aibei Biotechnology	Cat# M1130
KOSM medium	Nanjing Aibei Biotechnology	Cat# M1430
Light oil (neat)	Sigma	Cat# M840
Deposited data
ChIP-Seq	This paper	CNSA: CNP0002833
16S rRNA sequencing	This paper	CNSA: CNP0002837
Metagenome	This paper	CNSA: CNP0002838
Critical commercial assays
TUNEL Assay Kit	Keygenbio	Cat# KGA703
Mouse FSH ELISA kits	MEIMIAN	Cat# MM-0566M1
Mouse E2 ELISA kit	MEIMIAN	Cat# MM-45654 M1
Human FSH ELISA kit	Bioswamp	Cat# HM10662
Human E2 ELISA kit	Bioswamp	Cat# HM10669
Human AMH ELISA kit	Bioswamp	Cat# HM10844
Lipofectamine 3000 Reagent	Thermo Fisher	Cat# L3000015
CCK-8 assay	Beyotime	Cat# C0038
Annexin V-FITC/PI apoptosis kit	MULTISCIENCES	Cat# 70-AP101-100
Reverse Transcription Kit	Toyobo	Cat# KMM-101
SYBR qPCR Mix	Toyobo	Cat# QPX-201
BCA protein assay kit	Thermo	Cat# 23227
Nuclear and Cytoplasmic Extraction Kit	Beyotime	Cat# P0028
Plus Enzymatic Chromatin IP Kit	Cell Signaling	Cat# 9005S
Dual-luciferase reporter gene system	Promega	Cat# PR-E1910
Experimental models: Organisms/strains
C56Bl/6J	SiPeiFu	N/A
Experimental models: Cell lines
Human granulosa cell line (KGNs)	ATCC	Cat# CL-0603
Mouse ovarian cancer cell line (ID8)	BNCC	Cat# BNCC339488
Mouse Lewis lung carcinoma cell line	BNCC	Cat# BNCC338433
Oligonucleotides
List of primers	Table S4	N/A
Software and algorithms
R	R Core Team	https://www.r-project.org/
GraphPad Prism 7	GraphPad Software	https://www.graphpad.com/
Python	Python Software Foundation	https://www.python.org