Table 3.

Results for risk-based HTE analysis

	Odds ratio (95% HDI)	Absolute difference (95% HDI)	P(harm)	%ROPE*
28-day mortality	1.13 (0.94–1.38)	0.03 (− 0.01 to 0.07)	0.90	0.17
Composite endpoint	1.41 (1.14–1.71)	0.07 (0.03–0.12)	0.99	< 0.01
DAFICU28	–	− 0.57 (− 1.40 to 0.30)†	0.91	0.85
Low quartile [0.188,0.38]	–	0.04 (− 0.60 to 0.68)†	0.55	1.00
Medium–low quartile (0.38,0.471]	–	− 0.71 (− 2.58 to 1.32)†	0.76	0.60
Medium–high quartile (0.471,0.618]	–	− 0.12 (− 2.15 to 1.76)†	0.54	0.73
High quartile (0.618,0.957]	–	− 1.64 (− 3.62 to 0.48)†	0.95	0.24

Results for 28-day mortality and composite endpoint are not reported according to quartiles due to lack of clear signal for interaction; only results for days alive and free of ICU at 28 days—DAFICU28—is reported across quartiles. Values inside brackets represent the cAPACHE II prediction quartile range. *Region of practical equivalence—ROPE—defined as 1% differences for 28-day mortality and compositive endpoint and as 1 day difference for DAFICU28. †difference in DAFICU28