Table 1.
Baseline Demographics and Characteristics of the Study Cohort
| Short Duration N = 51 |
Long Duration N = 111 |
P Value | |
|---|---|---|---|
| Age, y, median (IQR) | 59 (47–71) | 59 (49–71) | NS |
| Male sex, n (%) | 29 (56.9) | 52 (46.8) | NS |
| Charlson Comorbidity Index score, median (IQR) | 6 (4–10) | 5 (3–8) | .033 |
| Comorbid conditions, n (%) | |||
| Active chemotherapy within last 90 d | 0 (0) | 0 (0) | NS |
| Autoimmune disorder | 2 (5.7) | 3 (2.4) | NS |
| Bone marrow transplant | 0 (0) | 0 (0) | NS |
| Congestive heart failure | 15 (29.4) | 37 (33.3) | NS |
| Chronic kidney disease | 14 (27.5) | 29 (26.1) | NS |
| COPD | 20 (39.2) | 41 (36.9) | NS |
| Connective tissue disorder | 2 (5.7) | 7 (6.3) | NS |
| CVA | 4 (7.8) | 10 (9) | NS |
| Diabetes | 15 (29.4) | 32 (28.8) | NS |
| Hematologic malignancy | 1 (2) | 5 (4.5) | NS |
| HIV infection | 7 (13.7) | 8 (7.2) | NS |
| Hypogammaglobinemia | 0 (0) | 0 (0) | NS |
| Mild liver diseasea | 17 (33.3) | 21 (18.9) | NS |
| Prior splenectomy | 1 (2) | 1 (0.9) | NS |
| Severe liver diseasea | 7 (13.7) | 9 (8.1) | NS |
| Solid organ transplant | 1 (2) | 1 (0.9) | NS |
| Allergies, n (%) | |||
| Penicillin allergy | 12 (23.5) | 12 (10.8) | NS |
| Non-penicillin antibiotic allergy | 5 (9.8) | 12 (10.8) | NS |
| Severity, n (%) | |||
| Met SIRS criteria | 24 (47.1) | 61 (55) | NS |
| ICU admission/transfer | 12 (23.5) | 34 (30.6) | NS |
| APACHE II score, median (IQR) | 6 (4–7) | 7 (4–13) | NS |
| Pitt bacteremia score ≥1, n (%) | 9 (17.6) | 11 (9.9) | NS |
Abbreviations: APACHE, Acute Physiology and Chronic Health Evaluation; COPD, chronic obstructive pulmonary disease; CVA, cerebral vascular accident; ICU, intensive care unit; NS, not significant; SIRS, systemic inflammatory response syndrome.
aMild liver disease, chronic hepatitis, or cirrhosis without portal hypertension; severe liver disease, cirrhosis, and portal hypertension with variceal bleeding history or cirrhosis and portal hypertension in the absence of variceal bleeding history.