Table 2.
Hospitalization Patient Characteristics and Antibiotic Choices
| Short Duration N = 51 |
Long Duration N = 111 |
P Value | |
|---|---|---|---|
| Infection type, n (%) | |||
| Pneumonia | 50 (98) | 96 (86.5) | .023 |
| Peritonitis | 0 (0) | 5 (4.5) | NS |
| Otitis media | 0 (0) | 4 (3.6) | NS |
| SSTI | 1 (0) | 3 (2.4) | NS |
| Endovascular | 0 (0) | 1 (0.9) | NS |
| Unknown etiology | 0 (0) | 2 (1.8) | NS |
| Initial inpatient antibiotic choice, n (%) | |||
| Beta-lactam | 10 (19.6) | 16 (14.4) | NS |
| Fluoroquinolone | 2 (3.9) | 3 (2.7) | NS |
| Vancomycin | 5 (9.8) | 8 (7.2) | NS |
| Combination beta-lactam and macrolide | 19 (37.3) | 43 (38.7) | NS |
| Combination beta-lactam and vancomycin | 10 (19.6) | 33 (29.7) | NS |
| Combination beta-lactam, vancomycin, and macrolide | 5 (9.8) | 8 (7.2) | NS |
| Initial outpatient antibiotic choice (monotherapy), n (%) | |||
| Beta-lactam | 8 (53.3) | 65 (79.3) | <.001 |
| Macrolide | 1 (6.7) | 4 (4.9) | NS |
| Fluoroquinolone | 6 (40) | 13 (15.9) | NS |
| Antibiotic resistance, n (%) | |||
| Azithromycin resistance | 13 (25.5) | 33 (29.7) | NS |
| Ceftriaxone resistance | 1 (2) | 6 (5.4) | NS |
| Fluoroquinolone resistance | 0 (0) | 0 (0) | NS |
| Penicillin resistance | 12 (23.5) | 21 (18.9) | NS |
| Tetracycline resistance | 2 (3.9) | 9 (8.1) | NS |
| Antibiotic duration, days, median (IQR) | |||
| Total | 7 (5–9) | 14 (13–15) | <.001 |
| Inpatient | 5 (5–7) | 5 (4–9) | .301 |
| Outpatient | 1 (0–4) | 7 (5–10) | <.001 |
Abbreviations: IQR, interquartile range; NS, not significant; SSTI, skin and soft tissue infection.