Figure 3. Evaluation of Escape From X Chromosome Inactivation (XCI).

All nonstratified lead variants for the 6 independent risk loci are shown reporting their sex-specific odds ratios (ORs), as well as the ratio of male to female β coefficients to assess evidence for escape from XCI (eTable 10 in Supplement 1). The male β coefficients here correspond to a 100% probability of association of the genotype. Ratios close to 2 suggest no escape from XCI, while ratios closer to 1 suggest escape from XCI.