Table 3.
Subgroup analysis of the associations between NLR and cardiovascular mortality among cancer participants.
| Subgroups | Participants N | Events N | HR | 95% CI | P value | P value for interaction |
|---|---|---|---|---|---|---|
| Age, year | 0.346 | |||||
| < 70 | ||||||
| Lower NLR | 1748 | 32 | Ref | |||
| Higher NLR | 727 | 29 | 1.53 | 0.81–2.88 | 0.184 | |
| > 70 | ||||||
| Lower NLR | 1390 | 150 | Ref | |||
| Higher NLR | 1109 | 190 | 1.79 | 1.37–2.32 | < 0.001 | |
| Gender | 0.241 | |||||
| Male | ||||||
| Lower NLR | 1316 | 93 | Ref | |||
| Higher NLR | 1023 | 153 | 1.98 | 1.40–2.81 | < 0.001 | |
| Female | ||||||
| Lower NLR | 1822 | 89 | Ref | |||
| Higher NLR | 813 | 66 | 1.27 | 0.87–1.87 | 0.211 | |
| Smoke | 0.252 | |||||
| Ever | ||||||
| Lower NLR | 1671 | 102 | Ref | |||
| Higher NLR | 1081 | 135 | 1.66 | 1.19–2.32 | 0.002 | |
| Never | ||||||
| Lower NLR | 1467 | 80 | Ref | |||
| Higher NLR | 755 | 84 | 1.49 | 0.97–2.28 | 0.064 | |
| HBP | 0.849 | |||||
| Yes | ||||||
| Lower NLR | 1688 | 122 | Ref | |||
| Higher NLR | 1109 | 165 | 1.73 | 1.29–2.33 | < 0.001 | |
| No | ||||||
| Lower NLR | 1450 | 60 | Ref | |||
| Higher NLR | 727 | 54 | 1.43 | 0.95–2.16 | 0.081 | |
Survey sample weights were taken into consideration in the Cox models accompanying the NHANES data. Multivariate Cox analysis was adjusted for gender, age, race, marital status, educational level, family income level, smoke history and the presence of comorbidities such as DM, CHD, HF, HBP, high cholesterol, stroke, chronic bronchitis and liver diseases.