Fig. 2. Progressive supranuclear palsy (PSP) candidate risk gene prioritization.

Datasets were GTEx (bulk RNA-seq) and Bryois et al (single nucleus RNA-seq) eQTLs across brain regions and purified cell types analyzed with COLOC. a All genes and loci shown with PP4 > 0.5 in at least one eQTL dataset. Point sizes are scaled to the magnitude of posterior probability of colocalization (PP4). *PP4 ≥ 0.75. OPC, Oligodendrocyte precursor cell. b Directions of effect on gene expression for STX6, MOBP, and RUNX2 relative to the risk allele (increased in frequency in PSP cases) of the lead GWAS SNP. Error bars denote standard error of the eQTL association.