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. 2024 Sep 9;7:1103. doi: 10.1038/s42003-024-06804-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 2 — Regional plot for two genome-wide significant loci in the UMOD (A), and SLC39A11 (B), and suggestive locus near TMEM106B/VWDE genes (C) identified in the meta- analysis of neurofilament light (NfL) genome-wide association study (GWAS) in European ancestry. The genetic variants are denoted as colored circles with their P values (-log10) on left Y-axis and genomic location is based on build 37 on X-axis. Lead SNPs (purple diamond) are marked with their genomic location. Recombination rates are plotted on right Y-axis to represent the local linkage disequilibrium (LD) structure. The LD between the genetic variants is provided with a color scale, ranging from blue (r2 = 0) to red (r2 = 1). LD calculations are based on 1000 genome, European ancestry.