Table 3A:
Incidence Rates and Sequential Cox Regression Analysis Using Macrosteatosis as a Prognostic Risk Factor for Specific Causes of Death
| Grade 1 Macrovesicular Steatosis | Grade 2 Macrovesicular Steatosis | Grade 3 Macrovesicular Steatosis | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| (A) Death due to Cardiac Arrest | |||||||||||
|
| |||||||||||
| Raw Incidence | Incidence Rates per 1000 Person-Years | Raw Incidence | Incidence Rates per 1000 Person-Years | Raw Incidence | Incidence Rates per 1000 Person-Years | ||||||
| Grade 1 Macrovesicular Steatosis | 264 | 5.02 | (4.43–5.66) | Grade 2 Macrovesicular Steatosis | 23 | 8.29 | (5.27-12.42) | Grade 3 Macrovesicular Steatosis | 4 | 6.19 | (1.69–15.78) |
| No Steatosis | 176 | 4.23 | (3.63–4.90) | No Steatosis | 176 | 4.23 | (3.63–4.90) | No Steatosis | 176 | 4.23 | (3.63–4.90) |
|
| |||||||||||
| Sequential Cox Regression Analysis | |||||||||||
|
| |||||||||||
| Model | p-value | aHR | 95% CI | Model | p-value | aHR | 95% CI | Model | p-value | aHR | 95% CI |
| 1 | 0.18 | 1.14 | (0.94–1.38) | 1 | 0.02 * | 1.71 | (1.11–2.64) | 1 | 0.47 | 1.44 | (0.53–3.89) |
| 2 | 0.20 | 1.13 | (0.94–1.37) | 2 | 0.02 * | 1.69 | (1.09–2.62) | 2 | 0.51 | 1.40 | (0.52–3.77) |
| 3 | 0.21 | 1.13 | (0.93–1.37) | 3 | 0.01 * | 1.75 | (1.13–2.71) | 3 | 0.54 | 1.36 | (0.50–3.68) |
| † FM | 0.42 | 1.08 | (0.89–1.32) | † FM | 0.03 * | 1.62 | (1.04–2.55) | † FM | 0.55 | 1.36 | (0.50–3.67) |
|
| |||||||||||
| (B) Death due to General Cardiac Causes | |||||||||||
|
| |||||||||||
| Raw Incidence | Incidence Rates per 1000 Person-Years | Raw Incidence | Incidence Rates per 1000 Person-Years | Raw Incidence | Incidence Rates per 1000 Person-Years | ||||||
| Grade 1 Macrovesicular Steatosis | 425 | 8.08 | (7.33–8.88) | Grade 2 Macrovesicular Steatosis | 31 | 11.18 | (7.61–15.83) | Grade 3 Macrovesicular Steatosis | 6 | 9.29 | (3.42–20.11) |
| No Steatosis | 294 | 7.07 | (6.29–7.92) | No Steatosis | 294 | 7.07 | (6.29–7.92) | No Steatosis | 294 | 7.07 | (6.29–7.92) |
|
| |||||||||||
| Sequential Cox Regression Analysis | |||||||||||
|
| |||||||||||
| Model | p-value | aHR | 95% CI | Model | p-value | aHR | 95% CI | Model | p-value | aHR | 95% CI |
| 1 | 0.20 | 1.10 | (0.95–1.28) | 1 | 0.07 | 1.40 | (0.97–2.03) | 1 | 0.50 | 1.32 | (0.59–2.97) |
| 2 | 0.23 | 1.10 | (0.94–1.27) | 2 | 0.08 | 1.39 | (0.96–2.02) | 2 | 0.55 | 1.28 | (0.57–2.87) |
| 3 | 0.24 | 1.09 | (0.94–1.27) | 3 | 0.05 | 1.44 | (1.00–2.10) | 3 | 0.56 | 1.27 | (0.57–2.86) |
| † FM | 0.35 | 1.07 | (0.92–1.25) | † FM | 0.08 | 1.41 | (0.96–2.06) | † FM | 0.56 | 1.27 | (0.57–2.87) |
|
| |||||||||||
| (D) Death due to Graft Rejection | |||||||||||
|
| |||||||||||
| Raw Incidence | Incidence Rates per 1000 Person-Years | Raw Incidence | Incidence Rates per 1000 Person-Years | Raw Incidence | Incidence Rates per 1000 Person-Years | ||||||
| Grade 1 Macrovesicular Steatosis | 76 | 1.45 | (1.14–1.81) | Grade 2 Macrovesicular Steatosis | 5 | 1.80 | (0.59–4.20) | Grade 3 Macrovesicular Steatosis | 0 | 0.00 | (0.00–5.69) |
| No Steatosis | 34 | 0.82 | (0.57–1.14) | No Steatosis | 34 | 0.82 | (0.57–1.14) | No Steatosis | 34 | 0.82 | (0.57–1.14) |
|
| |||||||||||
| Sequential Cox Regression Analysis | |||||||||||
|
| |||||||||||
| Model | p-value | aHR | 95% CI | Model | p-value | aHR | 95% CI | Model | p-value | aHR | 95% CI |
| 1 | 0.006 ** | 1.77 | (1.18–2.65) | 1 | 0.14 | 2.02 | (0.79–5.18) | 1 | 1.00 | 0.00 | (0.00-Inf) |
| 2 | 0.006 ** | 1.77 | (1.18–2.65) | 2 | 0.14 | 2.03 | (0.79–5.20) | 2 | 1.00 | 0.00 | (0.00-Inf) |
| 3 | 0.006 ** | 1.76 | (1.17–2.63) | 3 | 0.11 | 2.18 | (0.84–5.63) | 3 | 1.00 | 0.00 | (0.00-Inf) |
| † FM | 0.006 ** | 1.78 | (1.18–2.68) | † FM | 0.18 | 1.94 | (0.73–5.18) | † FM | 1.00 | 0.00 | (0.00-Inf) |
|
| |||||||||||
| (F) Death due to General Infectious Causes | |||||||||||
|
| |||||||||||
| Raw Incidence | Incidence Rates per 1000 Person-Years | Raw Incidence | Incidence Rates per 1000 Person-Years | Raw Incidence | Incidence Rates per 1000 Person-Years | ||||||
| Grade 1 Macrovesicular Steatosis | 545 | 10.36 | (9.51–11.27) | Grade 2 Macrovesicular Steatosis | 24 | 8.66 | (5.55–12.85) | Grade 3 Macrovesicular Steatosis | 3 | 4.64 | (0.96–13.51) |
| No Steatosis | 409 | 9.83 | (8.91–10.83) | No Steatosis | 409 | 9.83 | (8.91–10.83) | No Steatosis | 409 | 9.83 | (8.91–10.83) |
|
| |||||||||||
| Sequential Cox Regression Analysis | |||||||||||
|
| |||||||||||
| Model | p-value | aHR | 95% CI | Model | p-value | aHR | 95% CI | Model | p-value | aHR | 95% CI |
| 1 | 0.69 | 1.03 | (0.90–1.17) | 1 | 0.24 | 0.78 | (0.52–1.18) | 1 | 0.17 | 0.45 | (0.15–1.41) |
| 2 | 0.71 | 1.02 | (0.90–1.17) | 2 | 0.24 | 0.78 | (0.52–1.18) | 2 | 0.17 | 0.45 | (0.14–1.40) |
| 3 | 0.69 | 1.03 | (0.90–1.17) | 3 | 0.34 | 0.82 | (0.54–1.24) | 3 | 0.15 | 0.44 | (0.14–1.37) |
| † FM | 0.92 | 1.01 | (0.88–1.15) | † FM | 0.61 | 0.90 | (0.59–1.36) | † FM | 0.19 | 0.47 | (0.15–1.46) |
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| (G) Death due to General Neurological Causes | |||||||||||
|
| |||||||||||
| Raw Incidence | Incidence Rates per 1000 Person-Years | Raw Incidence | Incidence Rates per 1000 Person-Years | Raw Incidence | Incidence Rates per 1000 Person-Years | ||||||
| Grade 1 Macrovesicular Steatosis | 95 | 1.81 | (1.46–2.21) | Grade 2 Macrovesicular Steatosis | 2 | 0.72 | (0.09–2.60) | Grade 3 Macrovesicular Steatosis | 1 | 1.55 | (0.04–8.60) |
| No Steatosis | 78 | 1.88 | (1.48–2.34) | No Steatosis | 78 | 1.88 | (1.48–2.34) | No Steatosis | 78 | 1.88 | (1.48–2.34) |
|
| |||||||||||
| Sequential Cox Regression Analysis | |||||||||||
|
| |||||||||||
| Model | p-value | aHR | 95% CI | Model | p-value | aHR | 95% CI | Model | p-value | aHR | 95% CI |
| 1 | 0.75 | 0.95 | (0.71–1.28) | 1 | 0.15 | 0.36 | (0.09–1.46) | 1 | 0.88 | 0.86 | (0.12–6.18) |
| 2 | 0.74 | 0.95 | (0.70–1.28) | 2 | 0.15 | 0.36 | (0.09–1.46) | 2 | 0.88 | 0.86 | (0.12–6.19) |
| 3 | 0.74 | 0.95 | (0.70–1.28) | 3 | 0.17 | 0.37 | (0.09–1.53) | 3 | 0.87 | 0.85 | (0.12–6.14) |
| † FM | 0.61 | 0.92 | (0.68–1.25) | † FM | 0.25 | 0.44 | (0.11–1.80) | † FM | 0.88 | 0.86 | (0.12–6.22) |
|
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| (H) Death due to General Renal Causes | |||||||||||
|
| |||||||||||
| Raw Incidence | Incidence Rates per 1000 Person-Years | Raw Incidence | Incidence Rates per 1000 Person-Years | Raw Incidence | Incidence Rates per 1000 Person-Years | ||||||
| Grade 1 Macrovesicular Steatosis | 143 | 2.72 | (2.29–3.20) | Grade 2 Macrovesicular Steatosis | 9 | 3.25 | (1.49–6.15) | Grade 3 Macrovesicular Steatosis | 2 | 3.10 | (0.38–11.14) |
| No Steatosis | 124 | 2.98 | (2.48–3.55) | No Steatosis | 124 | 2.98 | (2.48–3.55) | No Steatosis | 124 | 2.98 | (2.48–3.55) |
|
| |||||||||||
| Sequential Cox Regression Analysis | |||||||||||
|
| |||||||||||
| Model | p-value | aHR | 95% CI | Model | p-value | aHR | 95% CI | Model | p-value | aHR | 95% CI |
| 1 | 0.34 | 0.89 | (0.70–1.13) | 1 | 0.99 | 1.01 | (0.51–1.98) | 1 | 0.97 | 1.03 | (0.25–4.15) |
| 2 | 0.35 | 0.89 | (0.70–1.14) | 2 | 0.90 | 1.04 | (0.53–2.06) | 2 | 1.00 | 1.00 | (0.25–4.06) |
| 3 | 0.35 | 0.89 | (0.70–1.13) | 3 | 0.78 | 1.10 | (0.56–2.18) | 3 | 0.94 | 0.95 | (0.23–3.86) |
| † FM | 0.28 | 0.87 | (0.68–1.12) | † FM | 0.82 | 1.09 | (0.54–2.17) | † FM | 0.95 | 0.96 | (0.24–3.89) |
|
| |||||||||||
| (I) Death due to General Respiratory Causes | |||||||||||
|
| |||||||||||
| Raw Incidence | Incidence Rates per 1000 Person-Years | Raw Incidence | Incidence Rates per 1000 Person-Years | Raw Incidence | Incidence Rates per 1000 Person-Years | ||||||
| Grade 1 Macrovesicular Steatosis | 197 | 3.75 | (3.24–4.31) | Grade 2 Macrovesicular Steatosis | 12 | 4.33 | (2.24–7.55) | Grade 3 Macrovesicular Steatosis | 2 | 3.10 | (0.38–11.14) |
| No Steatosis | 146 | 3.51 | (2.97–4.13) | No Steatosis | 146 | 3.51 | (2.97–4.13) | No Steatosis | 146 | 3.51 | (2.97–4.13) |
|
| |||||||||||
| Sequential Cox Regression Analysis | |||||||||||
|
| |||||||||||
| Model | p-value | aHR | 95% CI | Model | p-value | aHR | 95% CI | Model | p-value | aHR | 95% CI |
| 1 | 0.66 | 1.05 | (0.85–1.30) | 1 | 0.73 | 1.11 | (0.61–2.00) | 1 | 0.85 | 0.87 | (0.22–3.52) |
| 2 | 0.69 | 1.05 | (0.84–1.30) | 2 | 0.72 | 1.11 | (0.62–2.01) | 2 | 0.84 | 0.86 | (0.21–3.49) |
| 3 | 0.65 | 1.05 | (0.85–1.30) | 3 | 0.66 | 1.14 | (0.63–2.06) | 3 | 0.80 | 0.84 | (0.21–3.38) |
| † FM | 0.54 | 1.07 | (0.86–1.33) | † FM | 0.90 | 1.04 | (0.57–1.90) | † FM | 0.78 | 0.82 | (0.20–3.33) |
|
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| (J) Death due to Sepsis | |||||||||||
|
| |||||||||||
| Raw Incidence | Incidence Rates per 1000 Person-Years | Raw Incidence | Incidence Rates per 1000 Person-Years | Raw Incidence | Incidence Rates per 1000 Person-Years | ||||||
| Grade 1 Macrovesicular Steatosis | 348 | 6.62 | (5.94–7.35) | Grade 2 Macrovesicular Steatosis | 16 | 5.77 | (3.30–9.35) | Grade 3 Macrovesicular Steatosis | 3 | 4.64 | (0.96–13.51) |
| No Steatosis | 257 | 6.18 | (5.45–6.98) | No Steatosis | 257 | 6.18 | (5.45–6.98) | No Steatosis | 257 | 6.18 | (5.45–6.98) |
|
| |||||||||||
| Sequential Cox Regression Analysis | |||||||||||
|
| |||||||||||
| Model | p-value | aHR | 95% CI | Model | p-value | aHR | 95% CI | Model | p-value | aHR | 95% CI |
| 1 | 0.66 | 1.04 | (0.88–1.22) | 1 | 0.43 | 0.81 | (0.49–1.35) | 1 | 0.59 | 0.73 | (0.23–2.28) |
| 2 | 0.67 | 1.04 | (0.88–1.22) | 2 | 0.44 | 0.82 | (0.50–1.36) | 2 | 0.59 | 0.73 | (0.23–2.28) |
| 3 | 0.65 | 1.04 | (0.88–1.22) | 3 | 0.54 | 0.85 | (0.51–1.41) | 3 | 0.56 | 0.71 | (0.23–2.23) |
| † FM | 0.80 | 1.02 | (0.87–1.20) | † FM | 0.93 | 0.98 | (0.58–1.63) | † FM | 0.67 | 0.78 | (0.25–2.44) |
*
p < 0.05,
**
p < 0.01,
***
p < 0.001
†
FM indicates Final Model
Footnote:
*
Model 1 includes VOI (variable of interest) and demographics; Model 2 includes Model 1 terms with the addition of comorbidities, and liver disease etiologies; Model 3 includes Model 2 terms with the addition of hepatic variables, MELD score, and liver laboratory markers; Model 4 includes Model 3 terms with the addition of donor demographics