Table 1.
Data source of exposures, outcomes, confounding factors and mediators
| Trait | Consortium | Sample Size | Population | Participants |
|---|---|---|---|---|
| Exposures | ||||
| hypothyroidism [20] | MRC-IEU | 463,010 | European |
9,674 cases 453,336 ncontrols |
| L-T4 [20] | MRC-IEU | 462,933 |
18,947 cases 443,986 ncontrols |
|
| Outcomes | ||||
| MI [21] | IEU-Website | 395,795 | European |
14,825 cases 2,680 ncontrols |
| HF [22] | HERMES | 977,323 |
47,309 cases 930,014 ncontrols |
|
| cardiac death | Finngen | -- |
17,793 cases 324,706 controls |
|
| Confunders | ||||
| SBP [23] | ICBP | 757,601 | European | -- |
| DBP [23] | ICBP | 757,601 | -- | |
| Metformin [20] | MRC-IEU | 462,933 | 11,552 ncases | |
|
451,381 ncontrols -- | ||||
| BMI [20] | MRC-IEU | 461,460 | ||
| diabetes [24] | IEU | 655,666 |
61,714 ncases 1,178 ncontrols |
|
| cholesterol [25] | UK Biobank | 437,878 | ||
| LDL [26] | IEU-Website | 343,621 | ||
| triglycerides [27] | UK Biobank | 441,016 | ||
| Mediators | ||||
| AF | FinnGen | --- | European | 10,516 ncases |
| 116,926 ncontrols | ||||
| Stroke | FinnGen | -- | 18,661 ncases | |
| 162,201 ncontrols | ||||
| Bradycardia [20] | MRC-IEU | 463,010 | 1,254 ncases | |
| 46,1756 ncontrols | ||||