Table 3.

Pleiotropy and heterogeneity test

Outcomes/Exposures	Pleiotropy test			Heterogeneity test
	MR-Egger			MR-Egger			Inverse variance weighting
	Intercept	SE	P	Cochran'sQ	Q_df	Q_pval	Q	Q_df	Q_pval
MI/L-T4	0.004	0.004	0.27	57.16	65	0.75	58.38	66	0.74
MI/hypothyroidism	0.014	0.007	0.05	20.10	24	0.70	24.29	25	0.50
HF/L-T4	-0.001	0.003	0.65	75.61	63	0.13	75.86	64	0.15

df  Degree of freedom, HF Heart failure, L-T4 Levothyroxine, MI Myocardial infarction, Q Heterogeneity statistic Q