Table 4.
The associations of genetically predicted L-T4 and hypothyroidism with MI or HF
| Exposure | Trait of adjustment | OR | P value |
|---|---|---|---|
| L-T4-MI | BMI | 7.32 (2.90-18.44) | <0.01 |
| DBP | 17.09 (4.69-62.25) | <0.01 | |
| SBP | 13.53 (4.12-44.46) | <0.01 | |
| Metformin | 7.14 (2.70-18.89) | <0.01 | |
| Diabetes | 13.47 (3.15-57.73) | <0.01 | |
| Cholesterol | 12.31 (3.91-38.74) | <0.01 | |
| LDL | 9.55 (1.85-49.33) | <0.01 | |
| triglycerides | 8.94 (3.17-25.24) | <0.01 | |
| Hypothyroidism-MI | BMI | 7.32 (2.90-18.44) | <0.01 |
| DBP | 1.07 (1.00-1.15) | 0.046 | |
| SBP | 1.15 (1.08-1.22) | <0.01 | |
| Metformin | 1.10 (1.04-1.17) | 0.002 | |
| L-T4-HF | BMI | 2.20 (1.11-4.39) | 0.024 |
| Diabetes | 62.64 (2.59-1512.67) | 0.011 | |
| Cholesterol | 41.00 (2.17-774.38)) | 0.01 | |
| LDL | 75.13 (1.90-2973.40) | 0.02 | |
| triglycerides | 64.02 (7.65-535.69) | <0.01 | |
| DBP | 2.74 (1.19-6.28) | 0.017 | |
| SBP | 3.26 (1.43-7.43) | <0.01 | |
| Metformin | 2.64 (1.29-5.39) | 0.007 | |
| Diabetes | 3.91 (1.69-9.06) | <0.01 | |
| Cholesterol | 3.91 (38.74-12.31) | <0.01 | |
| LDL | 2.85 (1.15-7.03)) | 0.02 | |
| triglycerides | 2.55 (1.17-5.56) | 0.02 |
BMI Body mass index, DBP Diastolic blood pressure, L-T4 Levothyroxine, OR Odds ratio, SBP Systolic blood pressure, LDL Low-density lipoprotein