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. 2024 Jul 23;13(9):898–911. doi: 10.1093/stcltm/szae047

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© The Author(s) 2024. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Reprogramming process and iPSC characterization. (A) Flowchart of iPSC manufacturing process with QC. (B) Top 7 most frequent Caucasian HLA haplotypes accessible for reprogramming from homozygous donors. R25 and R26 are iPSC lines derived from distinct individuals. (C) Probabilities of identifying matching patients with a given set of HLA-homozygous iPSC lines in the Caucasian population. Open circles in the bottom chart: reprogrammed iPSC lines with pending QC. Filled circles in same chart: released iPSC lines. Two released lines share the same (most frequent) HLA haplotype. (D) Exemplary characterization data of 4 reprogrammed iPSC lines showing the indicated features and markers.