Table I.
Details of the synthetic peptides
| Peptide (group) | Protein region | CD31 domain | Sequence |
|---|---|---|---|
| SP1374 (I) | Gln70-Lys89 | 1 | QHQMLFYKDDVLFYNISSMK-Ttds-Ttds-Ttds-Ttds-KN3-CONH2 |
| SP1072 (II) | Tyr107-Glu122 | 1 | YKSTVIVNNKEKTTAE-PEG4-K(N3)-NH2 |
| SP1071 (III) | Pro133-Lys158 | 2 | Ac-K(N3)-PEG4-PRVTLDKKEAIQGGIVRVNSSVPEEK-CONH2 |
| SP1379 (IVa) | Thr106-Gln124 + Gln70-Lys89 (K8hC) | 1 (dimer)a | [-CH2COa-GTYKSTVIVNNKEKTTAEYQ-(Ttds)4-K(N3)-NH2]-[QHQMLFY-hCa-DDVLFYNISSMK-NH2] |
| SP1383 (IVb) | Pro133-Lys158 + K8hCGln70-Lys89 | 1-2 (dimer)a | [Ac-K(N3)-(Ttds)4-PRVTLDKKEAIQGGIVRVNSSVPEEK-Ttds-K(-CH2COa)NH2]-[QHQMLFY-hCa-DDVLFYNISSMK-NH2] |
a
Dimers are obtained through a thioether linkage of the first sequence with the bromoacetyl group of the second sequence.