TABLE 2.

Mild behavioral impairment associations with AD structural neuroimaging biomarkers.

Outcome variable	NC			MCI
Exposure variable	β	95% CI	p	β	95% CI	p
Hippocampus
Non‐MBI NPS	−0.24	−0.40 to −0.08	.004	−0.28	−0.60 to 0.05	.09
MBI	−0.38	−0.67 to −0.09	.01	−0.40	−0.73 to −0.07	.02
Entorhinal cortex
Non‐MBI NPS	−0.06	−0.21 to 0.09	.44	−0.17	−0.43 to 0.10	.22
MBI	−0.08	−0.35 to 0.18	.55	−0.37	−0.63 to −0.10	.008
AD meta‐ROI
Non‐MBI NPS	−0.12	−0.28 to 0.04	.14	−0.04	−0.37 to 0.30	.83
MBI	−0.50	−0.78 to −0.21	.001	−0.39	−0.73 to −0.05	.03

Note: All table values have been rounded to two decimal places, with the exception of p‐values which have been rounded to two or three decimal places, as appropriate. All beta coefficients indicate normalized deviations in the corresponding structural measure (outcome variable) from a normative sample of NC older adults as a function of NPS group (exposure variable), after adjusting for years of education completed, participant race/ethnicity, time elapsed between clinical and scanning visits, and the number of APOE4 alleles. The AD signature meta‐ROI consisted of the entorhinal cortex, inferior temporal gyrus, middle temporal gyrus, and fusiform gyrus. Bolded p‐values indicate an association that met the statistical significance threshold of p < .05.

Abbreviations: 95% CI, 95% confidence interval; AD, Alzheimer's disease; APOE4, apolipoprotein E e4; MBI, mild behavioral impairment; MCI, mild cognitive impairment; NC, normal cognition; NPS, neuropsychiatric symptoms; ROI, region of interest.