Table 1.
Summary of demographic and clinical characteristics of the sample.
| TRD (35) | TSD (35) | HC (38) | F/t/X^2 | sig | |
|---|---|---|---|---|---|
| Demographics | |||||
| Age, Mean ± SD [Min-Max] | 42.3 ± 14.1 [18.1–64.3] | 37.2 ± 11.0 [20.0–57.4] | 47.1 ± 14.3 [18.9–66.0] | n.s. | n.s. |
| Gender (M), N (%) | 14 (40 %) | 17 (48.6 %) | 17 (44.7 %) | n.s. | n.s. |
| Clinical Profile | |||||
| Age of onset, Mean ± SD [Min-Max] | 26.97 ± 13.13 [8–53] | 21.66 ± 9.26 [8–50] | n.a | n.s. | n.s. |
| Number of previous MDE, Mean ± SD [Min-Max] | 8 ± 11 [1–40] | 6 ± 6 [1–30] | n.a | n.s. | n.s. |
| Severity of worst MDE, Mean ± SD [Min-Max] | 6.77 ± 0.49 [5–7] | 5.21 ± 1.36 [3–7] | n.a | 6.346 | 0.000 |
| Length of current episode, days, Mean ± SD [Min-Max] | 117.1 ± 117.2 [14–365] | n.a. | n.a | n.a. | n.a. |
| HAM-D-21 score, Mean ± SD [Min-Max] | 25.23 ± 6.46 [16–41] | 4.18 ± 3.10 [0–9] | n.a | 15.819 | 0.000 |
| SOFAS score, Mean ± SD [Min-Max] | 73.91 ± 16.18 [40–100] | 89.58 ± 5.47 [78–95] | n.a | −5.275 | 0.000 |
| Antidepressant medication treatment past, N (%) | 31 (88.6 %) | 30 (85.7 %) | n.a. | 76.152 | < 0.001 |
| Antidepressant medication treatment current, N (%) | 19 (54.3 %) | 22 (62.9 %) | n.a. | 37.393 | < 0.001 |
| Length of time on antidepressant medication, years, Mean ± SD [Min-Max] | 4.44 ± 3.70 [0.17 – 12.0] | 4.18 ± 4.16 [0.12 – 17.0] | n.a. | n.s. | n.s. |
| History of Hospitalizations, N (%) | 25 (71.4 %) | 6 (17.1 %) | n.a | 20.902 | 0.000 |
| History of ECT, N (%) | 10 (28.6 %) | 0 (0) | n.a | 11.667 | 0.001 |
| History of TMS, N (%) | 3 (8.6 %) | 0 (0) | n.a | n.a. | n.a. |
| History of Suicidal Ideation, N (%) | 28 (80 %) | 26 (74.3 %) | n.a | n.s. | n.s. |
| History of Suicidal Attempt, N (%) | 19 (54.3 %) | 5 (14.3 %) | n.a | 13.938 | 0.000 |
n.a. – not applicable, n.s. – not significant; SD – Standard Deviation; M – male; MDE – Major Depressive Episode; HAMD-21 – Hamilton Depression Rating Scale, 21 items; SOFAS – Social and Occupational Functioning Assessment Scale; CGI-S – Clinical Global Impression, Severity; ECT – Electroconvulsive Therapy; TMS – Transcranial Magnetic Stimulation; N – total number.