Table 3.
Summary of the main findings from Independent Component Analyses (ICA), for differences between the three groups on functional connectivity between the best matching DMN component (ICA#15) and other brain regions.
| Contrast | MNI coordinates (x y z) | Voxels | Region | Neural network | F value | P value | Post-hoc |
|---|---|---|---|---|---|---|---|
| TSD>TRD | −10––92 26 | 144 | Left Cuneus Cortex | Visual | 7.430 | < 0.001 | TSD>TRD, HC |
| 10––84 20 | 90 | Right Cuneus Cortex | Visual | 6.112 | 0.003 | TSD>TRD, HC | |
| TRD>TSD | −44––72 38 | 117 | Left Angular Gyrus | Default Mode Network | 9.302 | < 0.001 | TRD>TSD, HC |
| TRD>HC | − | − | − | − | ns | ns | − |
| HC>TRD | − | − | − | − | ns | ns | − |
| TSD>HC | − | − | − | − | ns | ns | − |
| HC>TSD | − | − | − | − | ns | ns | − |
Effects significant at cluster-size False Discovery Rate p < 0.05; cluster size k > 20.
TRD – treatment-resistant depression group, TSD – treatment-sensitive depression group, HC – healthy controls groupns – not significant.