Table 2. Factors associated with time to EDSS progression, continuous MLBG, multivariable regression.

	HR (95% CI)	P
Larger MLBG, per SD increase	0.84 (0.72 to 0.99)	0.04*
Male sex	1.60 (1.12 to 2.27)	0.009*

Multivariable Cox regression. Likelihood ratio test p=0.02.

Non-significant covariates omitted from the table: age, baseline NBV, baseline T2LV, relapse within previous 2 years, PBVC.

^*p<0.05.

EDSS, expanded disability status scale; MLBG, maximal lifetime brain growth; PBVC, percentage brain volume change; T2LV, T2 lesion volume.