Table 3. Factors associated with time to EDSS progression, dichotomous MLBG, multivariable regression.

	HR (95% CI)	P
Larger MLBG than median	0.62 (0.45 to 0.87)	0.005*
Male sex	1.59 (1.12 to 2.25)	0.01*

Multivariable Cox regression. Likelihood ratio test p=0.006.

Nonsignificant covariates omitted from the table: age, baseline NBV, baseline T2LV, relapse within previous 2 years, PBVC.

^*p<0.05.

EDSS, expanded disability status scale; MLBG, maximal lifetime brain growth; PBVC, percentage brain volume change.