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. 2024 Sep 10;81(1):393. doi: 10.1007/s00018-024-05426-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Nusinersen modulates CSF proteome at T302. The change in clustering based on proteomics between T0 and T302 is shown for (a) SMA1, (b) SMA2, and (c) SMA3 patients, based on second- and third-dimension combinations. PCA plots showing distribution and clustering of samples, and ellipses correspond to 95% confidence intervals for each time point. Volcano plots are used to show the down- or up-regulated proteins after nusinersen treatment for (d) SMA1, (e) SMA2, and (f) SMA3 samples. Significantly changed proteins (p.adj < 0.05) were colored on volcano plots based on their higher (orange) or lower (blue) abundances at T302 compared to T0