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. 2024 Sep 10;81(1):393. doi: 10.1007/s00018-024-05426-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Biological processes modulated by nusinersen at T302. Top 20 GO pathways for biological processes (BP) enriched by mainly down-regulated (a-c) and up regulated DEPs (d-f), obtained from two clusters from each heatmap, are shown by lollipop plots for each SMA type. Fold enrichment represents the ratio of the percentage of matched proteins in the query list with pathway-associated proteins to the percentage of query with the background. Bar colors are corresponding to the false discovery rate (FDR) corrected p values for each enriched pathway, and the size of dots are proportional to the number of proteins associated with the respective pathway