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. 2024 Sep 10;81(1):393. doi: 10.1007/s00018-024-05426-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Responders vs. non-Responders analysis. The clustering patterns of the responders (green) and non-responders (dark grey) based on changes in protein levels after nusinersen treatment were shown by PCA plots based on first two dimensions for (a) SMA1, (c) SMA2, and (d) SMA3. Each dot represents one sample, and ellipses correspond to 95% confidence intervals for each of the subtypes. (b) Volcano plot for comparison of time-wise changes in protein levels in each responder and non-responder samples. Fold change differences were calculated by subtracting log2 fold change of proteins between T302 and T0 in non-responders from log2 fold change between T302 and T0 in responders, and higher and lower changes in responders compared to non-responders were shown by orange and blue colors, respectively