Table 2.

Risk of dementia in hypertensive patients compared to the general population.

	Adjusted HR (95%CI)
	All-cause dementia	Alzheimer disease	Vascular dementia
Model1	1.187 (1.116, 1.261)	1.175 (1.072, 1.288)	1.549 (1.339, 1.793)
P-value	< 0.001	0.001	< 0.001
Model2	1.118 (1.101, 1.266)	1.137 (1.023, 1.264)	1.565 (1.330, 1.841)
P-value	< 0.001	0.017	< 0.001
Model3	1.152 (1.070, 1.240)	1.124 (1.006, 1.256)	1.452 (1.225, 1.720)
P-value	< 0.001	0.039	< 0.001
Model4	1.149 (1.059,1.247)	1.137 (1.006,1.286)	1.281 (1.061,1.548)
P-value	0.001	0.040	0.010

Model 1: adjusted for basic socio-demographic characteristics [age; sex; ethnicity; education level; occupation status; TDI; BMI].

Model 2: adjusted for Model 1 and lifestyle [smoking status; dietary patterns; alcohol consumption; physical activity; social contact; duration of sedentary behavior].

Model 3: adjusted for Model 2 and health-related issues [family history of dementia; APOE genotype; depression; history of cancer; history of cardiovascular disease].

Model 4: adjusted for Model 3 and serum markers and drug use [Aspirin use status; lipid-lowering medications use status; dyslipidemia; hypertriglyceridemia; serum 25(OH)D status].