Table 3.
Comparisons of motor symptoms and quality of life between the clinical subtypes based on OH status
| SOH (n = 224) | LOH (n = 321) | NOH (n = 383) | P | |
|---|---|---|---|---|
| MDS-UPDRS (mean ± SD) | ||||
| Total scores | 101.5 ± 27.7a | 100.6 ± 26.7a | 88.7 ± 31.0 | <0.001# |
| Part I | 14.2 ± 6.2a | 13.7 ± 6.0a | 11.4 ± 5.8 | <0.001# |
| Part II | 20.3 ± 8.7a | 20.0 ± 8.5a | 16.7 ± 8.5 | <0.001# |
| Part III | 57.1 ± 18.6a | 57.1 ± 17.7a | 50.1 ± 19.6 | <0.001# |
| Part IV | 6.7 ± 3.9 | 7.0 ± 4.1a | 5.7 ± 4.2 | 0.002# |
| PDQ-39 (mean ± SD) | ||||
| Total scores | 51.3 ± 20.7a | 47.6 ± 20.8a | 41.0 ± 22.6 | <0.001# |
| Mobility | 17.1 ± 9.9a | 15.8 ± 9.9a | 12.3 ± 10.1 | <0.001# |
| Activities of daily living | 9.9 ± 5.6a | 9.2 ± 5.8a | 7.5 ± 6.0 | <0.001# |
| Emotion | 7.1 ± 4.5a, b | 6.1 ± 4.6a | 5.0 ± 4.5 | <0.001# |
| Stigma | 5.4 ± 4.0a | 5.1 ± 4.0 | 4.5 ± 4.2 | 0.004# |
| Social support | 1.3 ± 1.5 | 1.2 ± 1.3 | 1.1 ± 1.6 | 0.054 |
| Cognition | 4.2 ± 2.7a, b | 3.5 ± 2.6a | 2.8 ± 2.5 | <0.001# |
| Communication | 2.1 ± 2.1a | 1.7 ± 1.7 | 1.6 ± 1.9 | <0.001# |
| Bodily discomfort | 3.0 ± 2.4a | 2.7 ± 2.2 | 2.5 ± 2.3 | 0.018 |
Bold words: significant values.
OH orthostatic hypotension, SOH spontaneous OH, LOH levodopa induced OH, NOH non-OH, MDS-UPDRS Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale, PDQ-39 Parkinson’s disease questionnaire 39 item version.
aP < 0.05, vs. NOH.
bP < 0.05, vs. LOH.
#P < 0.05, adjusted for age and duration (Multiple Linear Regression).