Table 1.
Most significantly recognized T. pallidum antigens in N.LT and S.LT rabbits
| ORF #a | Putative gene function | Normalized IgG binding (Nichols-infected rabbits/SS14-infected rabbits)b | Seroprevalence (%) N.LT/S.LT rabbits |
Time to 100% seroprevalence (day) N.LT/S.LT rabbits |
|---|---|---|---|---|
| Tp0772 | Hypothetical protein/transcriptional regulator | 7.20/7.34 | 100/100 | 20/20 |
| Tp0684 | MglB/glucose-galactose binding lipoprotein | 6.89/7.09 | 100/100 | 10/20 |
| Tp0435 | TpN17 lipoprotein | 6.31/6.90 | 100/100 | 20/20 |
| Tp0768 | TmpA lipoprotein | 6.74/6.91 | 100/100 | 20/20 |
| Tp0567 | FlbB/flagellar protein | 6.37/6.34 | 100/100 | 20/20 |
| Tp0319 | TmpC/membrane lipoprotein; possible ABC transporter solute binding lipoprotein | 6.31/6.47 | 100/100 | 20/10 |
| Tp0326 | BamA/OMP assembly factor | 6.05/6.42 | 100/100 | 20/30 |
| Tp0574 | TpN47 lipoprotein | 6.01/6.03 | 100/100 | 20/10 |
| Tp0486 | Hypothetical protein | 5.54/6.78 | 100/100 | 10/20 |
| Tp0453 | Concealed OMP | 5.69/5.77 | 100/100 | 20/20 |
| Tp0727 | FlgE/flagellar hook protein | 5.68/5.83 | 100/100 | 20/20 |
| Tp0841 | DegQ/serine endoprotease | 5.36/6.06 | 100/100 | 20/20 |
| Tp0954 | Lipoprotein/putative adhesin | 4.78/5.37 | 100/100 | 30/30 |
| Tp0625 | Hypothetical protein | 4.85/5.41 | 100/100 | 30/30 |
| Tp0398 | FliE/flagellar hook-basal body complex protein | 4.29/4.88 | 100/100 | 30/50 |
| Tp0872 | FliD/flagellar filament capping protein | 4.76/5.41 | 100/100 | 30/50 |
| Tp0259 | LysM/peptidoglycan-binding domain-containing protein | 4.99/5.14 | 100/100 | 20/20 |
| Tp0369 | BamD/OMP assembly factor BamD | 3.95/4.65 | 100/100 | 30/40 |
| Tp0971 | TpD/iron transporter lipoprotein | 4.73/5.06 | 100/100 | 10/20 |
| Tp0468 | Tetratricopeptide repeat protein | 4.08/5.36 | 100/100 | 20/30 |
| Tp0433 | Hypothetical protein | 3.77/4.52 | 100/100 | 40/70 |
| Tp0225 | Leucine-rich repeat domain-containing protein | 3.62/5.65 | 100/100 | 20/20 |
| Tp0277 | Ctp peptidase | 3.84/5.25 | 100/100 | 30/30 |
| Tp0993 | RlpA/septal ring lytic transglycosylase | 3.24/4.14 | 100/100 | 30/40 |
| Tp1016 | Peptidyl-prolyl cis-trans isomerase | 2.86/5.40 | 100/100 | 30/30 |
| Tp0618 | Hypothetical protein | 3.31/4.43 | 100/100 | 30/40 |
| Tp0100 | TlpA/disulfide reductase | 3.66/4.71 | 100/100 | 30/40 |
| Tp0257 | GpD/glycerophosphodiester phosphodiesterase | 4.02/4.19 | 100/100 | 20/20 |
| Tp0594 | Hypothetical protein | 3.83/4.29 | 100/100 | 30/40 |
| Tp0737 | Periplasmic binding protein ABC transporter | 3.76/3.46 | 100/100 | 30/50 |
The line plot is selecting antigens by the means of the maxes for each rabbit. For each protein, the maximum of all time points for each rabbit is calculated, and then the mean of those maxes is assigned as the value to sort by.
a
Based on the annotation of the Nichols (NC_021490.2) and SS14 strain (NC_021508.1) genomes.
b
Mean reactivity values over 90 days post-infection.