Fig. 3.

Plasma CTSD levels in patients with MetALD/ALD stratified by AST/ALT ratio at cut-off level 2.

∗∗p <0.01, ∗∗∗∗p <0.0001 compared to healthy controls and ^#p <0.05 compared to MetALD/ALD patients with AST/ALT ratio ≤2 (indicated in graph as ‘AST/ALT ratio ≤2’) (Kruskal-Wallis test). All error bars are median with interquartile range. (healthy controls, n = 38; AST/ALT ratio ≤2, n = 116; AST/ALT ratio >2, n = 32). ALD, alcohol-related liver disease; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CTSD, cathepsin D; MetALD, metabolic dysfunction and alcohol-related liver disease.