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. 2024 Aug 23;107:105288. doi: 10.1016/j.ebiom.2024.105288

Table 2.

Comparison of tolerability and duration of therapy in DT 1 and DT < 1 cohorts.

N = 138 [blood tests not available for one patient] N DT 1 (N = 61) DT < 1 (N = 77) Chi-square/Fisher's Exact p value
Hemoglobin g/dl nadir
 <8 34 22 (36%) 12 (16%) 0.010
  8 104 39 (64%) 65 (84%)
Absolute neutrophil count (ANC)/dl nadir
 <1000 10 7 (11%) 3 (4%) 0.10
  1000 128 54 (89%) 74 (96%)
Platelet/dl nadir
 <50,000 6 4 (3%) 2 (3%) 0.41
  50,000 132 57 (93%) 75 (93%)
Olaparib dose reduction
 Yes 30 14 (23%) 16 (21%) 0.96
 No 109 48 (77%) 61 (79%)
Duration of olaparib therapy
 Days (median, IQR) 204 (127–319) 103 (72–158) <0.0001