Table 2. Cox regression model and propensity score analysis, stratified for resected and non-resected groups.

Variables	Univariate analysis			Multivariate analysis*			Propensity score multivariate analysis
	HR (95% CI)	P		aHR (95% CI)	P		ps-aHR (95% CI)	P
Resected
Period of surgery
Pre-MDT	Ref			Ref			Ref
Post-MDT	0.75 (0.62–0.92)	0.005		0.78 (0.64–0.95)	0.01		0.73 (0.59–0.90)	0.003
Treatment
Surgery +/− RT	Ref			Ref			Ref
Trimodality therapy	0.51 (0.40–0.65)	<0.0001		0.55 (0.42–0.72)	<0.0001		0.55 (0.42–0.74)	<0.0001
Surgery + systemic therapy	0.80 (0.64–1.00)	0.06		0.80 (0.62–1.02)	0.07		0.82 (0.63–1.07)	0.14
Non-resected
Period of surgery
Pre-MDT	Ref			Ref			Ref
Post-MDT	0.62 (0.48–0.79)	0.0001		0.62 (0.48–0.80)	0.0002		0.58 (0.44–0.77)	0.0001
Treatment
Systemic therapy	Ref			Ref			Ref
Chemoradiotherapy	0.82 (0.61–1.10)	0.19		0.85 (0.63–1.14)	0.28		0.84 (0.61–1.14)	0.35
No chemotherapy	4.11 (3.05–5.55)	<0.0001		3.99 (2.94–5.43)	<0.0001		4.16 (3.01–5.75)	<0.0001

*, adjusted for sex and age at the diagnosis. HR, hazard ratio; CI, confidence interval; MDT, multidisciplinary team; Ref, reference; RT, radiotherapy; ps-a, propensity score-adjustment.