Table 3. Cox regression examination investigating the impact of clinicopathological variables on patients’ overall survival.

Variables	Univariable Cox regression			Multivariable Cox regression
	HR (95% CI)	P		HR (95% CI)	P
Gender (male)	0.689 (0.361–1.313)	0.69
Age	0.998 (0.976–1.021)	0.88
Smoking	1.834 (1.120–3.002)	<0.001		2.945 (1.858–4.667)	<0.001
Tumor volume	1.003 (1.002–1.004)	<0.001		1.003 (1.002–1.004)	<0.001
Tumor differentiation (Low)	6.453 (3.974–10.477)	<0.001		4.285 (2.553–7.191)	<0.001
Gene mutation	0.170 (0.077–0.372)	<0.001		0.208 (0.094–0.463)	<0.001
Complication	1.618 (1.062–2.466)	0.03		1.156 (0.756–1.766)	0.50
Neutrophil	1.315 (1.145–1.510)	<0.001		1.287 (1.157–1.432)	<0.001
Monocyte	1.181 (0.273–5.104)	0.82
Lymphocyte	0.590 (0.410–0.849)	0.004		0.447 (0.308–0.650)	<0.001
Platelet	1.001 (0.998–1.004)	0.55

HR, hazard ratio; CI, confidence interval.