Table 7.

Green extraction methods of Scutellariae radix.

Methods	Optimal extraction conditions	Extracted components	Reference
Ultrasound-assisted deep eutectic solvents	Betaine: acetic molar ratio 1:4, water content 40 %, extraction temperature 52 °C, extraction time 23 min, and liquid-solid ratio 1:100 g/mL	Total flavonoids from SR	[144]
Microwave-assisted deep eutectic solvents	L-proline: urea molar ratio 2:1, water content 40 %, extraction temperature 110 °C, extraction time 20 min, and liquid-solid ratio 40 mL/g	Baicalin, baicalein and wogonin	[145]
Deep eutectic solvent-based ultrahigh pressure extraction	Choline chloride: lactic acid molar ratio 1:1, water content 40 %, pressure 400 MPa, extraction time 4 min, and liquid-solid ratio 110 mL/g	Baicalin	[146]
Ultrasound-assisted enzymatic extractin	Cellulase concentration 1.1 %, pH 5.5, extraction temperature 56.5 °C, extraction time 39.4 min, and ultrasonic power 200 W	Baicalein and wogonin	[147]
Ultrasound-assisted enzymatic extraction	Cellulase concentration 165.6 U/mL, extraction temperature 57.3 °C, extraction time 50 min, ultrasonic power 225 W, and liquid-solid ratio 44.8 mL/g	The polysaccharides of SR	[148]
Enzyme-assisted extraction	Cellulase concentration 20 U/mL, cellulase digestion time 24 h, pH 7.0, and extraction time 3 h	Baicalin	[149]
Ionic liquid-based microwave-assisted extraction	[C8mim]Br concentration 1.0 M, irradiation time 90 s, irradiation power 400 W, and liquid-solid ratio 1:6 (g/mL)	Flavonoids	[150]
Ultrasound-assisted ionic liquid-based liquid-liquid extraction	Volume ratio 3:3, extraction time 60 min, ultrasound-assisted extraction time 5 min, temperature 70 °C, and liquid-solid ratio 1:40	Baicalin and baicalein	[151]