Table 2.

Summary of nocturnal AE questionnaire.

Question, n (%)	Switch Participants N = 130
In the past 3 months, have you ever experienced anxiety or concerns related to taking the second dose of IR oxybate?
Yes	39 (30.0)
In the past 3 months, have you ever combined your first and second IR oxybate doses?
Yes	4 (3.1)
In the past 3 months, have you ever taken more or less of the prescribed second dose of IR oxybate?
More	1 (0.8)
Less	32 (24.6)
In the past 3 months, have you ever gotten out of bed after awakening to take your second dose of IR oxybate?
Yes	120 (92.3)
If yes, have you ever fallen after awakening for your second dose of IR oxybate?	9 (7.5)a
If yes, have you ever injured yourself after awakening for your second dose of IR oxybate?	5 (4.2)a
In the past 3 months, have you experienced any other side effects (eg, bed wetting, sleep walking/eating) after awakening to take your second dose of IR oxybate?
Yes	38 (29.2)
In the past 3 months, have you felt sick to your stomach after taking your second dose of IR oxybate?
Yes	27 (20.8)
In the past 3 months, have you needed to do something to prevent possible negative effects of taking the second dose of IR oxybate (putting up gates/have another person wake up with you)?
Yes	11 (8.5)
In the past 3 months, have you ever needed to have another person wake up with you to ensure you take your second dose of IR oxybate?
Yes	30 (23.1)
In the past 3 months, has there ever been an instance when you woke up to take your second dose of IR oxybate to find that it was missing?
Yes	1 (0.8)

^aPercentage calculated with a denominator of n = 120 participants. IR oxybate includes Xyrem® (Jazz Pharmaceuticals, Inc., Palo Alto, CA) or Xywav® (Jazz Pharmaceuticals, Inc., Palo Alto, CA). IR, immediate-release.