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. 2024 Jul 18;65(9):100599. doi: 10.1016/j.jlr.2024.100599

Fig. 3.

Fig. 3

Zone-specific localisation of the significant hepatic lipids altered in control and MASH. A–D: Two-sided bar plots illustrate lipid alterations across two zones (periportal, PT, and pericentral, CV) in control and MASH samples. A and B: Zone-specific localization of the decreasing lipids in the MASH stage. C and D: Zone-specific localization of the increasing lipids in the MASH stage. E: Ion images and box plots displayed the spatial distribution of FA20:4 and FA 22:6 in the periportal (PT) and pericentral (CV) of control and MASH samples. ∗P-value < 0.05, ∗∗P-value < 0.01, ∗∗∗P-value < 0.001 and ∗∗∗∗P-value < 0.0001 the pericentral areas of each group compared with the periportal areas, ####P-value < 0.0001 the MASH compared with the control (box plot (E)).